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KMID : 0384119870070020329
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Korean Journal of Clinical Pathology
1987 Volume.7 No. 2 p.329 ~ p.344
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A Case of Hemolytic Disease of Newborn Caused by IgG Anti-B in a B, Rho(D) Positive Newborn Whose Mother is O, Rho(D) Negative
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Abstract
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ABO & Rh isoimmunization is the major cause of neonatal hyperbilirubinemia. Recently we experienced a case of hemolytic disease of a B, Rho(D)?positive newborn due to IgG Anti-B. The newborn´s mother was 0, Rho(D) negative who had a history of four times of pregnancies, receiving Rho(D) immune globulin immediately after deliveries or abortion to prevent Rho(D) immunization.: The newborn´s red blood cells showed positivity in direct Coombs´test and the specifity was confirmed as IgG anti-B by ether eluates. The mother´s serum treated with gruop specific A, B substance showed IgG. Anti-A titer of 1 : 256, and IgG Anti-B titer of 1 : 2048 by anti-human golbulin phase. The newborn was treated with exchange transfusions with 0 Rho(D) negative packed red cells and fresh AB, Rho(D) positive plasmas, resulting improvement of hyperbilirubinemia.
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